Recent and future applications of ultrasound-activated piezoelectric nanoparticles for anticancer treatment: mini-review

Abstract Piezoelectric nanomaterials have the ability to control cancer cells from a distance. Chronic stimulation using ultrasound-driven piezoelectric nanoparticles can reduce cell growth by inducing cycle arrest. This method presents promising solution minimize undesirable effects. Numerous in vitro studies with various types of shown that chronic interferes multiple oncogenes, tumor suppressor gene, modifying balance proliferation and calcium homeostasis, leading upregulation K+ channel gene expression, resulting arrest G0/G1 phase. Additionally, affects organization mitotic spindles during mitosis modifies cytoskeleton capable disrupting normal function cells, their destruction. Evidence anticancer effects has been demonstrated osteosarcoma, colorectal cancer, breast glioblastoma multiforme, showing potential wide antitumor effect nanomaterials.